The model has four children - Leni with ex-partner Flavio Briatore and Henry, Johan and Lou with estranged husband Seal.
Klum is hoping to ensure her brood is cared for, long after she's gone.
"I want to make a brand that can stand alone without me, that I can give to my kids. Every parent wants to pass something along. You worry. Are they going to find the right job? The right person to love, to make them happy?
"Are they going to get into trouble: drugs, drink driving? I want to help them - I think about them more and more as I get older," she told the March edition of UK InStyle.
"I'm not worried about wrinkles, I just want to give my children a good foundation."
Klum appreciates her fortunate life. However, the beauty would give it all up in a heartbeat for the sake of her family.
"I don't need people to pull me back down to earth. I know I lead a crazy life, can buy what I want, put my kids in amazing schools and go on holiday anywhere in the world.
"I know how lucky I am. Yet, should it all evaporate, I'm ready to roll up my sleeves and get my hands dirty. I know what my priorities are: family. It's the only thing any of us truly have," she said.
"The rest is smoke and mirrors. If the house was burning down, the only thing I'd rescue would be the kids."