Holmes, 33, will appear in 2013 print ads and displays. Bobbi Brown will also be the lead make-up artist at the spring-summer 2013 fashion show for Holmes's clothing line, Holmes & Yang.
Holmes, whose divorce from actor Tom Cruise became final on August 21, is also appearing on Broadway this year in Theresa Rebeck's five-character Dead Accounts and also recently shot an adaptation of Chekhov's The Seagull.
Bobbi Brown Cosmetics, created by make-up artist Bobbi Brown in 1991, offers make-up, skin-care products, perfume and accessories in 60 countries and is owned by Estee Lauder Cos.